Ionil shampoo topical solution 200 ml

Ionil shampoo topical solution 200 ml

Action and mechanism

Keratolytic, antiseptic and antipruritic effective for the symptomatic relief of desquamative, psoriasiform and seborrhoeic dermatitis of the scalp.

Pharmacokinetics

Topical dermal route: Studies show that after topical administration there is cutaneous absorption of coal tar and salicylic acid, however the amounts absorbed into plasma were always very low.

Plasma concentrations after topical administration of 10-20 g of 6% salicylic acid gel under occlusion for 10 hours were very low (less than or equal to 5 mg/100 ml) and well below toxic levels (40 mg/100 ml). The patterns of metabolism, protein binding and excretion after topical administration of salicylic acid are identical to those of systemic administration.

Taking into account that in clinical practice, the amount administered is approximately 15 ml per application and that ionyl shampoo contains 2% salicylic acid and 4.25% coal tar, the amount per application of each active substance cannot be more than 0.3 g and 0.6375 g, respectively, i.e. for an average weight of 70 kg, it could not be more than 0.0042 g/kg and 0.091 g/kg of salicylic acid and coal tar, respectively.

Indications

- Symptomatic relief of scalp desquamative disorders such as [SEBORRheic DERMATITIS], [Psoriasis], [DANDRUFF] and [Itching].

Posology

- Topical: 1 or 2 times a week, for 2 to 4 weeks or as often as required for the treatment of the hair disorder.

Rules for correct administration

apply the shampoo on wet hair. Massage gently and rinse. Repeat the operation, leaving the product to act for a few minutes before rinsing. Rinse thoroughly.

Contraindications

- Hypersensitivity to any of the components of the formulation.

Precautions

- Avoid contact with eyes and mucous membranes. If the product accidentally comes into contact with eyes, rinse with clean, lukewarm water.

- In case of acute inflammation, open [INJURIES] and skin [INFECTION], the benefit/risk ratio should be evaluated.

Interactions

Concomitant use of coal tar or coaltar with photosensitising medicinal products may produce additive photosensitising effects. Concomitant use of coal tar with systemic or topical methoxalene or trioxalene is not recommended.

Children

In children, there may be an increased risk of secondary toxicity due to increased absorption of salicylic acid through the skin and the higher ratio of body surface area to surface area treated, so caution should be exercised in children.

Adverse reactions

Occasionally: erythema, dryness, contact dermatitis, folliculitis, skin irritation, acneiform rash, burning or stinging sensation and rarely skin photosensitivity.